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REVIEW article
Front. Immunol.
Sec. Microbial Immunology
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1438989
Integrating Pathogen-and Host-Derived Blood Biomarkers for Enhanced Tuberculosis Diagnosis: A Comprehensive Review
Provisionally accepted
Zhaodong Li
1
Yunlong Hu
1
Wenfei Wang
2
Fa Zou
1
Jing Yang
1
Wei Gao
1
Siwan Feng
1
Guanghuan Chen
1
Chenyan Shi
1
Yi Cai
1
Guofang Deng
2*
Xinchun Chen
1*- 1 Shenzhen University, Shenzhen, China
- 2 Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, China
This review explores the evolving landscape of blood biomarkers in the diagnosis of tuberculosis (TB), focusing on biomarkers derived both from the pathogen and the host. These biomarkers provide critical insights that can improve diagnostic accuracy and timeliness, essential for effective TB management. The document highlights recent advancements in molecular techniques that have enhanced the detection and characterization of specific biomarkers. It also discusses the integration of these biomarkers into clinical practice, emphasizing their potential to revolutionize TB diagnostics by enabling more precise detection and monitoring of the disease progression. Challenges such as variability in biomarker expression and the need for standardized validation processes are addressed to ensure reliability across different populations and settings. The review calls for further research to refine these biomarkers and fully harness their potential in the fight against TB, suggesting a multidisciplinary approach to overcome existing barriers and optimize diagnostic strategies. This comprehensive analysis underscores the significance of blood biomarkers as invaluable tools in the global effort to control and eliminate TB.
Keywords: Tuberculosis, Mycobacterium tuberculosis, biomarker, blood test, Molecular diagnosis
Received: 27 May 2024; Accepted: 24 Jul 2024.
Copyright: © 2024 Li, Hu, Wang, Zou, Yang, Gao, Feng, Chen, Shi, Cai, Deng and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guofang Deng, Shenzhen Third People’s Hospital, Shenzhen, Guangdong Province, China
Xinchun Chen, Shenzhen University, Shenzhen, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.