AUTHOR=Pita-Martínez Carlos , Goez-Sanz Carmen , Virseda-Berdices Ana , Gonzalez-Praetorius Alejandro , Mazario-Martín Esther , Rodriguez-Mesa María , Quero-Delgado Marta , Matías Vanesa , Martínez Isidoro , Resino Salvador TITLE=Reduced antiviral gene expression and elevated CXCL8 expression in peripheral blood are associated with severe hypoxemia in RSV-infected children JOURNAL=Frontiers in Immunology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1438630 DOI=10.3389/fimmu.2024.1438630 ISSN=1664-3224 ABSTRACT=
The pathology of respiratory syncytial virus (RSV) infection remains unclear. An unbalanced immune response to RSV infection can lead to immunopathology, causing airway damage and impaired exchange of oxygen and carbon dioxide between the air and the bloodstream. We aimed to evaluate the association of the expression of inflammatory and antiviral genes in peripheral blood with severe hypoxemia in children with RSV infection seen in the hospital emergency room. We conducted a cross-sectional study on 121 RSV-infected children seen in hospital emergency rooms between 2015 and 2023. Total RNA was extracted from whole blood samples, and gene expression (