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REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1438272
The emerging role of neutrophil extracellular traps in the progression of rheumatoid arthritis disease
Provisionally accepted- Anhui University of Chinese Medicine, Hefei, China
Rheumatoid arthritis (RA) is a chronic autoimmune disease with complex etiology. Neutrophil extracellular traps (NETsare NETswork protein structures activated by neutrophils to induce the cleavage and release of DNA-protein complexes.Current studies have shown the critical involvement of NETs in the progression of autoimmune diseases, Neutrophils mostly gather in the inflammatory sites of patients and participate in the pathogenesis of autoimmune diseases in various ways. NETs, as the activated state of neutrophils, have attracted much attention in immune diseases. Many molecules released in NETs are targeted autoantigens in autoimmune, such as histones, citroline peptides, MPO, etc. All of these suggest that NETs have a direct causal relationship between the production of autoantigens and autoimmune diseases. Especially for RA, as a disorder of innate and adaptive immune response, the pathogenesis of RA is inseparable from the generation of RA. In this paper, we investigate the emerging role of NETs in the pathogenesis of RA and suggest that NETs may be an important target for the treatment of inflammatory autoimmune diseases.
Keywords: Neutrophil extracellular trap, Rheumatoid arthritis, Autoantibody, citrullination, Key role
Received: 25 May 2024; Accepted: 19 Jul 2024.
Copyright: © 2024 Chen, Cao, Xiao, Hong and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yang Cao, Anhui University of Chinese Medicine, Hefei, China
Yujie Hong, Anhui University of Chinese Medicine, Hefei, China
Yan Zhu, Anhui University of Chinese Medicine, Hefei, China
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