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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1435334
This article is part of the Research Topic Immunological Precision Therapeutics: Integrating Multi-Omics Technologies and Comprehensive Approaches for Personalized Immune Intervention View all 11 articles

Mucosal Microbiota Characterization in Gastric Cancer Identifies Immuneactivated-Related Transcripts Relevant Gastric Microbiome Signatures

Provisionally accepted
Chengjia Qian Chengjia Qian 1Jiang Hui Jiang Hui 1Ziyao Peng Ziyao Peng 2Xiaoyan Sun Xiaoyan Sun 3Jiali Zhang Jiali Zhang 4*
  • 1 Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China
  • 2 Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
  • 3 Department of Nuclear Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China
  • 4 Central Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Tumor microenvironment (TME) immune cells and gastric mucosal microbiome constitute two vital elements of tumor tissue. Increasing evidence has elucidated their clinicopathological significance in predicting outcomes and therapeutic efficacy.However, comprehensive characterization of immune cell-associated microbiome signatures in the TME is still in the early stages of development. Here, we characterized the gastric mucosa microbiome and its associations with immune-activated related transcripts (IATs) in 170 GC tumor tissues and matched non-tumor tissues using 16s rRNA gene sequencing and quantitative reverse transcription-PCR. Microbial diversity and richness were significantly higher in GC tumor tissues than in non-tumor tissues.Differences in microbial composition between the groups were evident, with Firmicutes,

    Keywords: Mucosal microbiota, gastric cancer, Immune-activated, transcripts, Gastric Microbiome Signatures

    Received: 20 May 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Qian, Hui, Peng, Sun and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiali Zhang, Central Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.