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REVIEW article

Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1435122
This article is part of the Research Topic Enhancing CAR T-Cell Therapy with Imaging View all 3 articles

The Interventional Radiologist's Role in CAR-T Cell Therapy

Provisionally accepted
Conor M Prendergast Conor M Prendergast *Alireza Baniasadi Alireza Baniasadi Sophia Huang Sophia Huang Zahra Biezavi Zahra Biezavi Abin Sajan Abin Sajan Kathleen M Capaccione Kathleen M Capaccione
  • Columbia University Irving Medical Center, Columbia University, New York, New York, United States

The final, formatted version of the article will be published soon.

    Chimeric antigen receptor T (CAR-T) therapy has been a boon to modern medicine in treating hematological malignancies. In recent years, steps have been taken to emulate that success with solid organ tumors, which are less susceptible to CAR-T therapy due to the physical barrier and physiology of the tumor microenvironment. This is where the interventional oncologist (IO), a subspecialty of interventional radiology (IR), may have an important role. In this article, we will review in general the background of CAR-T cells and the procedures and techniques of interventional oncology, and then delve into how the IO physician can augment CAR-T cell therapy, explore CAR-T cell adverse events, and then discuss emerging new innovations and potential for further collaboration between interventional oncology and CAR-T cell therapy.

    Keywords: interventional radiology (IR), Interventional oncology (IO), CAR T cancer therapy, Immunotherapy, Radiomics, Immune adverse events

    Received: 19 May 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Prendergast, Baniasadi, Huang, Biezavi, Sajan and Capaccione. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Conor M Prendergast, Columbia University Irving Medical Center, Columbia University, New York, NY 10027, New York, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.