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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1435021

Regulatory T cells and macrophages in atherosclerosis: from mechanisms to clinical significance

Provisionally accepted
Xin Ouyang Xin Ouyang 1Zhongyong Liu Zhongyong Liu 2*
  • 1 School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China
  • 2 Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China

The final, formatted version of the article will be published soon.

    Atherosclerosis is a complex pathological process, which causes diseases that threaten the health of an increasing number of people. Studies have found that the original view of lipid accumulation is not comprehensive because the use of lipid-lowering drugs alone cannot effectively treat atherosclerosis. As the study of the pathogenesis of atherosclerosis develops in-depth, the impact of immune-inflammatory response on atherosclerosis has garnered a great deal of attention. Some new advances have been made in the role of regulatory T cells (Tregs) and macrophages with unique immunomodulatory functions in atherosclerosis. Herein, the role of Tregs, macrophages, the mechanisms of Tregs-regulated macrophages, and the effects of potential factors on Tregs and macrophages in atherosclerosis are overviewed. Targeting Tregs and macrophages may provide new research strategies for the treatment of atherosclerosis in the clinic.

    Keywords: cardiovascular disease, Atherosclerosis, regulatory T cells, Tregs, Macrophages

    Received: 19 May 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Ouyang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhongyong Liu, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.