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REVIEW article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1432841

Spatial multi-omics analysis of the microenvironment in traumatic spinal cord injury： a narrative review

Provisionally accepted
Run Peng Run Peng 1,2liang zhang liang zhang 1,2Yongqi Xie Yongqi Xie 2Shuang Guo Shuang Guo 2Xinqi Cao Xinqi Cao 2*Mingliang Yang Mingliang Yang 2*
  • 1 School of Rehabilitation Medicine, China Rehabilitation Research Center, Capital Medical University, Beijing, China
  • 2 China Rehabilitation Research Center, Capital Medical University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Traumatic spinal cord injury (tSCI) is a severe injury to the central nervous system that is categorized into primary and secondary injuries. Among them, the local microenvironmental imbalance in the spinal cord caused by secondary spinal cord injury includes accumulation of cytokines and chemokines, reduced angiogenesis, dysregulation of cellular energy metabolism, and dysfunction of immune cells at the site of injury, which severely impedes neurological recovery from spinal cord injury (SCI). In recent years, single-cell techniques have revealed the heterogeneity of multiple immune cells at the genomic, transcriptomic, proteomic, and metabolomic levels after tSCI, further deepening our understanding of the mechanisms underlying tSCI. However, spatial information about the tSCI microenvironment, such as cell location and cell-cell interactions, is lost in these approaches. The application of spatial multi-omics technology can solve this problem by combining the data obtained from immunohistochemistry and multiparametric analysis to reveal the changes in the microenvironment at different times of secondary injury after SCI. In this review, we systematically review the progress of spatial multi-omics techniques in the study of the microenvironment after SCI, including changes in the immune microenvironment and discuss potential future therapeutic strategies.

    Keywords: single cell, Single Cell RNA sequencing, Spatial transcriptomics, spatial multi-omics, microenvironment, immune microenvironment, heterogeneity, spinal cord injury

    Received: 14 May 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Peng, zhang, Xie, Guo, Cao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xinqi Cao, China Rehabilitation Research Center, Capital Medical University, Beijing, 100068, Beijing Municipality, China
    Mingliang Yang, China Rehabilitation Research Center, Capital Medical University, Beijing, 100068, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.