Skip to main content

ORIGINAL RESEARCH article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1432041

Causal Association between Circulating Inflammatory Proteins and Peripheral Artery Disease : a bidirectional two-sample Mendelian randomization study

Provisionally accepted
Juncheng Zhao Juncheng Zhao 1,2Bo Sun Bo Sun 1,2*Shujie Huang Shujie Huang 2*Yunhui Chen Yunhui Chen 2*Jingqiang Yan Jingqiang Yan 2*
  • 1 Qingdao Municipal Hospital, Qingdao, China
  • 2 Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, Shandong Province, China

The final, formatted version of the article will be published soon.

    Introduction: A growing body of research has shown a strong connection between circulating inflammatory proteins and Peripheral artery disease (PAD). However, the causal relationship between circulating inflammatory proteins and PAD is still not fully understood. To investigate this association, we conducted a bidirectional Mendelian randomization study.Materials and Methods: Our study utilized genetic variation data obtained from genome-wide association studies (GWAS) datasets. Specifically, the GWAS dataset related to PAD (identifier: finn-b-I9_PAD) included 7,098 cases and 206,541 controls. Additionally, we extracted data on 91 inflammatory proteins from another GWAS dataset (identifiers: GCST90274758-GCST90274848), involving 14,824 participants. To assess the causal relationship between circulating inflammatory proteins and PAD development, we employed methodologies such as inverse variance weighting (IVW), MR Egger regression, and the weighted median approach. Furthermore, sensitivity analyses were conducted to ensure the reliability and robustness of our findings.Results: Two inflammatory proteins were found to be significantly associated with PAD risk: Natural killer cell receptor 2B4 levels (OR, 1.

    Keywords: peripheral artery disease, circulating inflammatory proteins, genome-wide association study, Mendelian randomization, causal association 219, 95% CI,1.019~1.457, P=0.03), Fractalkine levels (OR, 0.755, 95% CI=0.591~0.965, P=0.025). PAD had statistically significant effects on 12 inflammatory proteins: C-C motif chemokine 19 levels (OR, 0.714, 95% CI, 0.585 to 0.872, P=0.001), T-cell surface glycoprotein CD5 levels (OR, 0.818, 95% CI, 0.713 to 0.938

    Received: 13 May 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Zhao, Sun, Huang, Chen and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bo Sun, Qingdao Municipal Hospital, Qingdao, China
    Shujie Huang, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, 266021, Shandong Province, China
    Yunhui Chen, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, 266021, Shandong Province, China
    Jingqiang Yan, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, 266021, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.