AUTHOR=Pena João Matheus Sobral , Lannes-Costa Pamella Silva , Nagao Prescilla Emy 

TITLE=Vaccines for Streptococcus agalactiae: current status and future perspectives

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1430901

DOI=10.3389/fimmu.2024.1430901

ISSN=1664-3224

ABSTRACT=<p>A maternal vaccine to protect newborns against invasive <italic>Streptococcus agalactiae</italic> infection is a developing medical need. The vaccine should be offered during the third trimester of pregnancy and induce strong immune responses and placental transfer of protective antibodies. Polysaccharide vaccines against <italic>S. agalactiae</italic> conjugated to protein carriers are in advanced stages of development. Additionally, protein-based vaccines are also in development, showing great promise as they can provide protection regardless of serotype. Furthermore, safety concerns regarding a new vaccine are the main barriers identified. Here, we present vaccines in development and identified safety, cost, and efficacy concerns, especially in high-need, low-income countries.</p>