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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1430825
This article is part of the Research Topic Impact of the Innate and Adaptive Immune System in Driving Type 1 Inflammatory Skin Disease View all 9 articles

Macrophages in inflammatory skin diseases and skin tumors

Provisionally accepted
SIHAN LIU SIHAN LIU 1,2Jie Zhang Jie Zhang 1,2Ya-gang Zuo Ya-gang Zuo 1,2*
  • 1 Department of Dermatology, Peking Union Medical College Hospital (CAMS), Beijing, Beijing Municipality, China
  • 2 State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma. We aim to contribute to illustrating the pathogenesis and potential new therapies for inflammatory skin diseases and skin tumors from the perspective of macrophages.

    Keywords: macrophage, Inflammatory skin diseases, Skin tumors, Pathogenesis, Treatment

    Received: 10 May 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 LIU, Zhang and Zuo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ya-gang Zuo, Department of Dermatology, Peking Union Medical College Hospital (CAMS), Beijing, 100730, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.