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REVIEW article

Front. Immunol.
Sec. Viral Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1430544
This article is part of the Research Topic Cellular and host immune responses in the context of dual viral infection View all articles

Unveiling the Multifaceted Realm of Human Papillomavirus: A Comprehensive Exploration of Biology, Interactions, and Advances in Cancer Management

Provisionally accepted
Meng Wu Meng Wu 1Hui Huang Hui Huang 2Ying Tang Ying Tang 3Xuze Ren Xuze Ren 4Xinrui Jiang Xinrui Jiang 5Tian Man Tian Man 6*Wei Li Wei Li 7*
  • 1 Department of Clinical Laboratory, Nanjing Children's Hospital, Nanjing, China
  • 2 Department of Rheumatology and Immunology, Nanjing Children's Hospital, Nanjing, Liaoning Province, China
  • 3 Department of Ultrasound Diagnostic, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China., Nanjing, China
  • 4 Department of Clinical Medicine, Clinical College of Anhui Medical University, Hefei, 230031, China, hefei, China
  • 5 Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
  • 6 Department of Respiratory, Children's Hospital of Nanjing Medical University, Nanjing, China, Nanjing, China
  • 7 Department of Clinical Research, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210008, China, Nanjing, China

The final, formatted version of the article will be published soon.

    Human Papillomavirus (HPV), an extensive family of DNA viruses, manifests as a persistent global health challenge. Persistent HPV infection is now firmly established as a significant aetiological factor for a spectrum of malignancies. In this review, we examine the latest insights into HPV biology and its intricate relationship with the host. We delve into the complex dynamics of co-infections involving HPV alongside other viruses, such as HIV, EBV, and HSV, as well as the burgeoning role of the microbiome in cancer development. We also explore recent advancements in understanding the specific contributions of HPV in the development of various cancers, encompassing cancers of the anogenital region, head and neck, as well as breast, lung, and prostate. Moreover, we focus on the current preventive strategies, including vaccination and screening methods, and therapeutic interventions that range from traditional approaches like surgery and chemotherapy to emerging modalities such as targeted therapies and immunotherapies. Additionally, we provide a forward-looking view on the future directions of HPV research, highlighting potential areas of exploration to further our understanding and management of HPV and its associated cancers. Collectively, this review is positioned to deepen readers' understanding of HPV biology and its complex interplay with cancer biology. It presents innovative strategies for the prevention, management, and therapeutic intervention of HPV-associated malignancies.

    Keywords: HPV, HPV-associated cancers, HPV vaccines, microRNA, cancer prevention

    Received: 10 May 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Wu, Huang, Tang, Ren, Jiang, Man and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tian Man, Department of Respiratory, Children's Hospital of Nanjing Medical University, Nanjing, China, Nanjing, China
    Wei Li, Department of Clinical Research, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210008, China, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.