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REVIEW article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1430356

Exploration of the pathogenesis of Nephrotic Syndrome and Traditional Chinese Medicine intervention based on Gut Microbiota

Provisionally accepted
Jing Li Jing Li 1Yupei Xu Yupei Xu 1Tianhao Sun Tianhao Sun 1Xiaotian Zhang Xiaotian Zhang 1Huimin Liang Huimin Liang 1Wei Lin Wei Lin 2Hangxing Yu Hangxing Yu 3Bo Yang Bo Yang 1Hongtao Yang Hongtao Yang 1*
  • 1 Department of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • 2 Department of Neurology, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian Province, China
  • 3 Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China

The final, formatted version of the article will be published soon.

    Nephrotic Syndrome (NS) represents a prevalent syndrome among various chronic kidney disease pathologies, known for a higher severity and worse prognosis compared to chronic glomerulonephritis. The quest for understanding its pathogenesis and identifying more effective treatment modalities has always long been a concern for kidney specialists. With the introduction of the gut-kidney axis concept and the progress made in omics technologies, alterations in the gut microbiota have been witnessed in primary and secondary NS. This link has been extensively researched in conditions such as diabetic nephropathy and IgA nephropathy. Thus, dysbiosis of the gut microbiota is seen as a crucial contributing factor in NS, while there is a lack of comprehensive reviews that elucidate the changes in gut microbiota across different NS conditions and detail its mechanistic role in the disease. Moreover, serving as an innate regulator of gut microbiota, traditional chinese medicine (TCM) has the potential to exert a profound impact on the expressions of inflammation-promoting agents, curtailing the levels of endotoxins and uremic toxins. Additionally, it emboldens the stability of the intestinal barrier whilst steering the metabolic function of the body through its skillful modulation of the gut microbiota. This intricate process yields far-reaching consequences for the NS.

    Keywords: Nephrotic Syndrome, Gut Microbiota, Pathogenesis, Traditional Chinese Medicine, Inflammation, immune response

    Received: 09 May 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Li, Xu, Sun, Zhang, Liang, Lin, Yu, Yang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hongtao Yang, Department of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.