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REVIEW article

Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1427784
This article is part of the Research Topic The Pivotal Role of Cytokines in Autoimmune Diseases View all articles

The Role of Cytokines in the Pathogenesis of SAPHO Syndrome

Provisionally accepted
Yi Yang Yi Yang Qianzhu Chen Qianzhu Chen Weiyang Zhong Weiyang Zhong *
  • Department of Orthopedics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    SAPHO syndrome is a complex inflammatory disorder affecting the skin and bones, characterized by osteomyelitis, acne, and pustulosis. Cytokines play a pivotal role in the pathogenesis of SAPHO syndrome, especially in inflammatory responses and immune regulation. This article reviews the cytokines involved in the pathogenesis of SAPHO syndrome, such as tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6, IL-10, and transforming growth factor-β (TGF-β), and discusses their potential as intervention points for treatment. These findings elucidate the intricate immune regulatory network of SAPHO syndrome and provide a theoretical foundation for the development of new targeted therapeutic strategies.

    Keywords: Data curation, Writing -original draft. Qianzhu Chen: Resources, Writing -review & editing. Weiyang Zhong: Conceptualization, Writing -original draft, Writing -review & editing SAPHO syndrome, Cytokines, TNF-α, IL-1 β

    Received: 04 May 2024; Accepted: 09 Jul 2024.

    Copyright: © 2024 Yang, Chen and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Weiyang Zhong, Department of Orthopedics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.