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SYSTEMATIC REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1427454
This article is part of the Research Topic Immunology at the feto-maternal interface View all 12 articles

Chronic Endometritis and recurrent reproductive failure: a systematic review and meta-analysis

Provisionally accepted
CARLO TICCONI CARLO TICCONI 1*Annalisa Inversetti Annalisa Inversetti 2,3Serena Marraffa Serena Marraffa 1Luisa Campagnolo Luisa Campagnolo 4Jephthah Arthur Jephthah Arthur 2Enrica Zambella Enrica Zambella 2Nicoletta Di Simone Nicoletta Di Simone 2,3
  • 1 Department of Surgical Sciences, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, Roma, Lazio, Italy
  • 2 Department of Biomedical Sciences, Humanitas University, Rozzano, Italy
  • 3 IRCCS, Humanitas Research Hospital, Rozzano, Lombardy, Italy
  • 4 Department of Biomedicine and Prevention, University of Rome Tor Vergata, Roma, Lazio, Italy

The final, formatted version of the article will be published soon.

    The endometrium holds a crucial role in reproduction by supporting blastocyst adhesion, cytotrophoblast invasion and fetal development. Among the various uterine disorders, endometritis, particularly chronic endometritis (CE), has gained attention due to its association with adverse reproductive outcomes (recurrent pregnancy loss (RPL), recurrent implantation failure (RIF), and infertility). The association between CE and adverse reproductive outcomes stresses the necessity for comprehensive diagnostic and therapeutic strategies to optimize fertility outcomes and support individuals in their journey towards parenthood.Aim: To explore the relationship between CE and reproductive disorders.Methods: Following PRISMA guidelines, a systematic review and meta-analysis using published data from 1990 to 2024 were carried out.Results: A population of 1,038 women was included. Regarding CE-infertility association, a positive correlation was found, with 19.46% CE rate in infertile women compared to 7.7% in controls (OR: 2.96, 95% CI 1.53-5.72, p 0.001). No significant association was observed between RIF and CE (OR:1.10, 95% CI 0.26-4.61, p 0.90), CE rates in both groups were relatively comparable, with 6.35% in women with RIF and 5.8% in controls. On the opposite, a strong association between CE and RPL was found, reporting a CE rate of 37.6% in RPL cases compared to 16.4% in controls (OR: 3.59, 95% CI 2.46-5.24, p < 0.00001).Conclusions: CE appears to be associated to infertility and RPL, while no significant association was noted in cases of RIF.

    Keywords: Chronic endometritis, Recurrent pregnancy loss, recurrent implantation failure, Infertility, reproductive failure chronic endometritis, Reproductive failure, Systematic review, Meta-analysis

    Received: 03 May 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 TICCONI, Inversetti, Marraffa, Campagnolo, Arthur, Zambella and Di Simone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: CARLO TICCONI, Department of Surgical Sciences, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, Roma, 00173, Lazio, Italy

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