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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1426418

Stem-like CD8+ T cells in Cancer

Provisionally accepted
Yiping Yang Yiping Yang *Chelsea Steiner Chelsea Steiner Nathan Denlinger Nathan Denlinger Xiaopei Huang Xiaopei Huang
  • The Ohio State University, Columbus, United States

The final, formatted version of the article will be published soon.

    Stem-like CD8 + T cells (TSL) are a unique subset of immune cells that exhibit increased persistence and antitumor immunity. They are TCF1 + PD-1 + and are essential for the antitumoral response in response to checkpoint blockade immunotherapy. TSL cells have stem-like properties similar to memory T cell populations and can give rise to effector T cell populations to induce tumor control. This review will cover the current research on the formation, expansion, differentiation, and maintenance niches required for the TSL population in cancer. We will also discuss clinical implications in generating these cells or enhancing stemness in current therapeutic approaches.

    Keywords: stem-like CD8 T cells (TSL), Chronic viral infection, Cancer models, immune, Tertiary lymphoid structure (TLS), tumor micro environment (TME)

    Received: 01 May 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Yang, Steiner, Denlinger and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yiping Yang, The Ohio State University, Columbus, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.