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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1424237
This article is part of the Research Topic Immune Cell Metabolic Reprogramming in Cancer Development and Therapy View all 4 articles

The role of metabolic reprogramming in immune escape of triple-negative breast cancer

Provisionally accepted
Ruochen Bao Ruochen Bao 1,2Hongtao Qu Hongtao Qu 3Baifeng Li Baifeng Li 1,2Kai Cheng Kai Cheng 1,3Yandong Miao Yandong Miao 1,2Jiangtao Wang Jiangtao Wang 1,2*
  • 1 Binzhou Medical University, Binzhou, China
  • 2 Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong Province, China
  • 3 Emergency Department of Yantai Mountain Hospital, Yantai, China

The final, formatted version of the article will be published soon.

    Triple-negative breast cancer (TNBC) has become a thorny problem in the treatment of breast cancer because of its high invasiveness, metastasis and recurrence. Although immunotherapy has made important progress in TNBC, immune escape caused by many factors, especially metabolic reprogramming, is still the bottleneck of TNBC immunotherapy. Regrettably, the mechanisms responsible for immune escape remain poorly understood. Exploring the mechanism of TNBC immune escape at the metabolic level provides a target and direction for follow-up targeting or immunotherapy. In this review, we focus on the mechanism that TNBC affects immune cells and interstitial cells through hypoxia, glucose metabolism, lipid metabolism and amino acid metabolism, and changes tumor metabolism and tumor microenvironment. This will help to find new targets and strategies for TNBC immunotherapy.

    Keywords: Triple-negative breast cancer, immune escape, hypoxia, glucose metabolism, Lipid Metabolism, amino acid metabolism

    Received: 27 Apr 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Bao, Qu, Li, Cheng, Miao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiangtao Wang, Binzhou Medical University, Binzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.