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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1423784
This article is part of the Research Topic Immunity and Inflammation in Diabetic Nephropathy View all 5 articles
The Role of Intercellular Communication in Diabetic Nephropathy
Provisionally accepted
Bihan Wang
1
Yonghong Xiong
1*
XinQi Deng
1*
Siyuan Gong
1*
Yunhao Wang
1*
Songyuan Yang
1
Baichuan Yang
1*
Yuhang Yang
2
Yan Leng
1
Wenyuan Li
1*
Wei Li
1*- 1 Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
- 2 Wuhan University, Wuhan, Hubei Province, China
Diabetic nephropathy, a common and severe complication of diabetes, is the leading cause of end-stage renal disease, ultimately leading to renal failure and significantly affecting the prognosis and lives of diabetics worldwide.However, the complexity of its developmental mechanisms makes treating diabetic nephropathy a challenging task, necessitating the search for improved therapeutic targets. Intercellular communication underlies the direct and indirect influence and interaction among various cells within a tissue. Recently, studies have shown that beyond traditional communication methods, tunnel nanotubes, exosomes, filopodial tip vesicles, and the fibrogenic niche can influence pathophysiological changes in diabetic nephropathy by disrupting intercellular communication. Therefore, this paper aims to review the varied roles of intercellular communication in diabetic nephropathy, focusing on recent advances in this area.
Keywords: diabetic nephropathy, intercellular communication, tunnel nanotube, exosome, filopodial tip vesicle, fibrogenic niche, single-cell RNA sequencing
Received: 26 Apr 2024; Accepted: 01 Aug 2024.
Copyright: © 2024 Wang, Xiong, Deng, Gong, Wang, Yang, Yang, Yang, Leng, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yonghong Xiong, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China
XinQi Deng, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China
Siyuan Gong, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China
Yunhao Wang, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China
Baichuan Yang, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China
Wenyuan Li, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China
Wei Li, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China
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