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CASE REPORT article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1423547

Case Report: Multi-Antibody-Positive Myasthenia Gravis Concomitant Myositis Associated with Thymoma

Provisionally accepted
Chao Huang Chao Huang 1Xuelian Dai Xuelian Dai 1*Bianli Yin Bianli Yin 1*Chao Liu Chao Liu 1*Xiangyang Ren Xiangyang Ren 1*Jiacheng Liu Jiacheng Liu 1,2*Yunting Zhang Yunting Zhang 1,2*Zhihui Duan Zhihui Duan 1*Yang Huan Yang Huan 1,3*
  • 1 Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
  • 2 Xinxiang Medical University, Xinxiang, Henan Province, China
  • 3 Xiangya Hospital, Central South University, Changsha, Hunan Province, China

The final, formatted version of the article will be published soon.

    Myasthenia gravis (MG) and idiopathic inflammatory myopathy (IIM) are autoimmune diseases of the nervous system, and their main clinical manifestation is muscle weakness. The concurrent presence of both conditions in the same patient is clinically rare and easily missed. Here, we report the case of a 74-year-old woman who went to the doctor with fluctuating weakness of the limbs and muscle pain. By analyzing the patient's history and the results of repeated frequency electrical stimulation, chest computed tomography, thigh muscle magnetic resonance imaging, serum antibody detection, lymph node biopsy, etc., she was finally diagnosed with MG-concomitant IIM with squamous cell carcinoma of the thymus. AChR antibody, Titin antibody, RyR antibody, anti-JO-1 antibody, and Ro-52 antibody tests were positive. MG-concomitant IIM is often associated with thymoma. The immunopathology mechanism may be different from that of pure MG or IIM, which needs further research.

    Keywords: Myasthenia Gravis, Acetylcholine receptor antibodies, Idiopathic inflammatory myopathy, Antisynthetase syndrome, Thymoma

    Received: 26 Apr 2024; Accepted: 15 Aug 2024.

    Copyright: © 2024 Huang, Dai, Yin, Liu, Ren, Liu, Zhang, Duan and Huan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xuelian Dai, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
    Bianli Yin, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
    Chao Liu, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
    Xiangyang Ren, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
    Jiacheng Liu, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China
    Yunting Zhang, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China
    Zhihui Duan, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
    Yang Huan, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China

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