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CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1423547
Case Report: Multi-Antibody-Positive Myasthenia Gravis Concomitant Myositis Associated with Thymoma
Provisionally accepted- 1 Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
- 2 Xinxiang Medical University, Xinxiang, Henan Province, China
- 3 Xiangya Hospital, Central South University, Changsha, Hunan Province, China
Myasthenia gravis (MG) and idiopathic inflammatory myopathy (IIM) are autoimmune diseases of the nervous system, and their main clinical manifestation is muscle weakness. The concurrent presence of both conditions in the same patient is clinically rare and easily missed. Here, we report the case of a 74-year-old woman who went to the doctor with fluctuating weakness of the limbs and muscle pain. By analyzing the patient's history and the results of repeated frequency electrical stimulation, chest computed tomography, thigh muscle magnetic resonance imaging, serum antibody detection, lymph node biopsy, etc., she was finally diagnosed with MG-concomitant IIM with squamous cell carcinoma of the thymus. AChR antibody, Titin antibody, RyR antibody, anti-JO-1 antibody, and Ro-52 antibody tests were positive. MG-concomitant IIM is often associated with thymoma. The immunopathology mechanism may be different from that of pure MG or IIM, which needs further research.
Keywords: Myasthenia Gravis, Acetylcholine receptor antibodies, Idiopathic inflammatory myopathy, Antisynthetase syndrome, Thymoma
Received: 26 Apr 2024; Accepted: 15 Aug 2024.
Copyright: © 2024 Huang, Dai, Yin, Liu, Ren, Liu, Zhang, Duan and Huan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuelian Dai, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
Bianli Yin, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
Chao Liu, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
Xiangyang Ren, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
Jiacheng Liu, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China
Yunting Zhang, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China
Zhihui Duan, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China
Yang Huan, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China
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