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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1423107

Scientific Issues with Rodent Models of Neuromyelitis Optic Spectrum Diseases

Provisionally accepted
Yusen Huang Yusen Huang 1Tianwei Wang Tianwei Wang 1Fangruyue Wang Fangruyue Wang 2Meiyan Shao Meiyan Shao 1Jia Ai Jia Ai 2Ying Zhang Ying Zhang 2Le Fang Le Fang 3*
  • 1 China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China
  • 2 The Third Bethune Hospital of Jilin University, Changchun, Hebei Province, China
  • 3 Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Neuromyelitis optica spectrum disease (NMOSD) is a rare autoimmune disorder that causes severe inflammation in the central nervous system (CNS), primarily affecting the optic nerves, spinal cord, and brainstem. Aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) are a diagnostic marker of the disease and play a significant role in its pathogenesis, though the exact mechanism is not yet fully understood. To develop rodent models that best simulate the in vivo pathological and physiological processes of NMOSD, researchers have been continuously exploring how to establish the ideal model. In this process, two key issues arise: 1) how the AQP4 antibody crosses the blood-brain barrier, and 2) the source of the AQP4 antibody. These two factors are critical for the successful development of rodent models of NMOSD. This paper reviews the current state of research on these two aspects.

    Keywords: Neuromyelitis optica spectrum disease, Autoimmune Diseases, animal model, AQP4-IgG, Autoantibodies

    Received: 25 Apr 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Huang, Wang, Wang, Shao, Ai, Zhang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Le Fang, Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.