AUTHOR=Lu Yun , Tang Xinyi , Wang Wenxin , Yang Jun , Wang Shengjun 

TITLE=The role of deacetylase SIRT1 in allergic diseases

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1422541

DOI=10.3389/fimmu.2024.1422541

ISSN=1664-3224

ABSTRACT=<p>The silent information regulator sirtuin 1 (SIRT1) protein is an NAD<sup>+</sup>-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and non-histone proteins. SIRT1 has been reported to be involved in several physiological or pathological processes such as aging, inflammation, immune responses, oxidative stress and allergic diseases. In this review, we summarized the regulatory roles of SIRT1 during allergic disorder progression. Furthermore, we highlight the therapeutic effects of targeting SIRT1 in allergic diseases.</p>