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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1421858
This article is part of the Research Topic Alternative Gene and Cell Therapies​ in Hyperinflammatory Diseases View all 7 articles

Exploring Mechanisms of Skin Aging: Insights for Clinical Treatment

Provisionally accepted
Meiqi Zhang Meiqi Zhang 1Yumeng Lin Yumeng Lin 2Han Zhongyu Han Zhongyu 1*Xuewen Huang Xuewen Huang 1Shuwei Zhou Shuwei Zhou 3Siyu Wang Siyu Wang 4Yan Zhou Yan Zhou 5Xuan Han Xuan Han 6Haoran Chen Haoran Chen 7
  • 1 Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • 2 Aoyang Hospital, Zhangjiagang, China
  • 3 School of Medicine, Southeast University, Nanjing, Jiangsu Province, China
  • 4 The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
  • 5 Guang Zhou Dermatology Hospital, Guang Zhou, China
  • 6 Changzhi Medical College, Changzhi, Shanxi Province, China
  • 7 Affiliated Chengdu Xinhua hospital of north Sichuan medical college, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    The skin is the largest organ in the human body and is made up of various cells and structures. Over time, the skin will age, which is not only influenced by internal factors, but also by external environmental factors, especially ultraviolet radiation. Aging causes immune system weakening in the elderly, which makes them more susceptible to dermatosis, such as type 2 inflammatory mediated pruritus. The immune response in this condition is marked by senescent cells consistently releasing low amounts of pro-inflammatory cytokines through a senescence-associated secretory phenotype (SASP). This continuous inflammation may accelerate immune system aging and establish a connection between immune aging and type 2 inflammatory skin diseases. In addition, two chronic pigmentation disorders, vitiligo and chloasma, are also associated with skin aging. Aged cells escape the immune system and accumulate in tissues, forming a microenvironment that promotes cancer. At the same time, "photoaging" caused by excessive exposure to ultraviolet radiation is also an important cause of skin cancer. This manuscript describes the possible links between skin aging and type 2 inflammation, chronic pigmentation disorders, and skin cancer and suggests some treatment options.

    Keywords: Aging, type 2 inflammatory, chronic pigmentary disorders, Skin Cancer, Skin

    Received: 23 Apr 2024; Accepted: 23 Oct 2024.

    Copyright: © 2024 Zhang, Lin, Zhongyu, Huang, Zhou, Wang, Zhou, Han and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Han Zhongyu, Chengdu University of Traditional Chinese Medicine, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.