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REVIEW article
Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1421854
This article is part of the Research Topic Exosome-Mediated Intercellular Communications: Immune Stimulation and Suppression View all 5 articles
Advances and clinical challenges of mesenchymal stem cell therapy
Provisionally accepted
Ruiyan Mei
1,2
Zhuo Wan
3
Cheng Yang
1,2
Xiangjing Shen
1,2
Ronglin Wang
1,2
Haihua Zhang
1,2
Rui Yang
1,2
Junqiang Li
1,2
Yang Song
1,2
Haichuan Su
1,2*- 1 Department of Oncology, Tangdu hospital,, Xi'an, China
- 2 Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province, China
- 3 Department of Hematology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
In recent years, cell therapy has provided desirable properties for promising new drugs. Mesenchymal stem cells are promising candidates for developing genetic engineering and drug delivery strategies due to their inherent properties, including immune regulation, homing ability and tumor tropism. The therapeutic potential of mesenchymal stem cells is being investigated for cancer therapy, inflammatory and fibrotic diseases, among others. Mesenchymal stem cells are attractive cellular carriers for synthetic nanoparticles for drug delivery due to their inherent homing ability. In this review, we comprehensively discuss the various genetic and non-genetic strategies of mesenchymal stem cells and their derivatives in drug delivery, tumor therapy, immune regulation, tissue regeneration and other fields. In addition, we discuss the current limitations of stem cell therapy and the challenges in clinical translation, aiming to identify important development areas and potential future directions.
Keywords: mesenchymal stem cell, cell homing, Drug delivery, Nanoparticles, clinical use
Received: 23 Apr 2024; Accepted: 02 Jul 2024.
Copyright: © 2024 Mei, Wan, Yang, Shen, Wang, Zhang, Yang, Li, Song and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haichuan Su, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province, China
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