AUTHOR=Krayem Imtissal , Grusanovic Srdjan , Duric Iris , Pavliuchenko Nataliia , Danek Petr , Borna Simon , Sekeresova Kralova Jarmila , Skopcova Tereza , Pokorna Jana , Alberich-Jorda Meritxell , Brdicka Tomas TITLE=WBP1L regulates hematopoietic stem cell function and T cell development JOURNAL=Frontiers in Immunology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1421512 DOI=10.3389/fimmu.2024.1421512 ISSN=1664-3224 ABSTRACT=
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which was shown to correlate with ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. It has a broad expression pattern in hematopoietic and non-hematopoietic cells. Our previous work described WBP1L as a regulator of CXCR4 signaling and hematopoiesis. Here, we show that hematopoiesis in the mice with