AUTHOR=Harris Duane C. , Shanker Apoorv , Montoya Makaela M. , Llewellyn Trent R. , Matuszak Anna R. , Lohar Aditi , Kubicek-Sutherland Jessica Z. , Li Ying Wai , Wilding Kristen , Mcmahon Ben , Gnanakaran Sandrasegaram , Ribeiro Ruy M. , Perelson Alan S. , Molina-París Carmen 

TITLE=Quantification of heterogeneity in human CD8+ T cell responses to vaccine antigens: an HLA-guided perspective

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1420284

DOI=10.3389/fimmu.2024.1420284

ISSN=1664-3224

ABSTRACT=<p>Vaccines have historically played a pivotal role in controlling epidemics. Effective vaccines for viruses causing significant human disease, <italic>e.g.</italic>, Ebola, Lassa fever, or Crimean Congo hemorrhagic fever virus, would be invaluable to public health strategies and counter-measure development missions. Here, we propose coverage metrics to quantify vaccine-induced CD8<sup>+</sup> T cell-mediated immune protection, as well as metrics to characterize immuno-dominant epitopes, in light of human genetic heterogeneity and viral evolution. Proof-of-principle of our approach and methods are demonstrated for Ebola virus, SARS-CoV-2, and <italic>Burkholderia pseudomallei</italic> (vaccine) proteins.</p>