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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1419420

Migrasome Regulator TSPAN4 Shapes the Suppressive Tumor Immune Microenvironment in Pan-Cancer

Provisionally accepted
Lin-jian Wang Lin-jian Wang *Ruiyan Xu Ruiyan Xu Yangyang Wu Yangyang Wu
  • Zhengzhou Central Hospital, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Migrasomes are newly discovered organelles located on the retracting fibers of migrating cells. They release various signaling molecules into the environment, expel damaged mitochondria from the cell, or are phagocytosed by receptor cells to complete intercellular information transmission. TSPAN4 serves as a highly valuable marker for visualizing migrasomes and is also an important regulator of migrasome formation. Currently, the function of TSPAN4 in cancer remains unclear. Here, we have discovered that TSPAN4 is aberrantly expressed in various tumors and may be closely associated with its methylation level. Additionally, we have revealed its prognostic significance in pan-cancer and identified its strong correlation with tumor heterogeneity and stemness, along with its involvement in shaping the suppressive tumor immune microenvironment through analysis of RNA-seq and scRNA-seq data.Furthermore, we conducted a detailed investigation of TSPAN4's involvement in glioma and determined that it affects glioma cell proliferation and facilitates the polarization of macrophages toward the immunosuppressive M2 type.

    Keywords: TSPAN4, Pan-cancer, prognosis, Glioma, Tumor immune microenvironment

    Received: 18 Apr 2024; Accepted: 27 Nov 2024.

    Copyright: © 2024 Wang, Xu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lin-jian Wang, Zhengzhou Central Hospital, Zhengzhou, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.