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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1419005

Exploring the Efficacy of Laser Speckle Contrast Imaging (LSCI) in the Stratified Diagnosis of Rosacea: A Quantitative Analysis of Facial Blood Flow Dynamics Across Varied Regions

Provisionally accepted
Jin-Feng Liao Jin-Feng Liao 1*Xue-Mei Jiang Xue-Mei Jiang 1*ZHEN XIE ZHEN XIE 1Hua Lei Hua Lei 1*Juan Luo Juan Luo 1*Yu Lv Yu Lv 1Gang Liu Gang Liu 1*Wei Liu Wei Liu 1*Si-Yuan Song Si-Yuan Song 2*Yi Wang Yi Wang 1*
  • 1 Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
  • 2 Baylor College of Medicine, Houston, Texas, United States

The final, formatted version of the article will be published soon.

    Background: Rosacea has a high incidence, significantly impacts quality of life, and lacks sufficient diagnostic techniques. This study aimed to investigate the feasibility of Laser Speckle Contrast Imaging (LSCI) for measuring facial blood perfusion in rosacea patients and to identify differences in blood flow among various facial regions associated with different rosacea subtypes. Methods: From June to December 2023, 45 patients were recruited, with 9 excluded, leaving 36 subjects: 12 with Erythematotelangiectatic Rosacea (ETR), 12 with Papulopustular Rosacea (PPR), and 12 healthy controls. The Think View multispectral imaging analyzer assessed inflammation via grey reading values across the full face and five facial areas: forehead, nose, cheeks, and chin. LSCI measured and analyzed blood perfusion in the same areas.Plasma biomarkers IL-6, IL-1β, and TNF-α were tested in different groups.Results:Both ETR and PPR groups showed increased average blood perfusion and facial inflammation intensity by grey values compared to controls, with statistically significant differences.Average blood perfusion of ETR and PPR groups showed increased in forehead,cheeks,nose,compared to controls,and the cheeks with statistically differences between ETR and PPR.The facial inflammation intensity of ETR groups showed increased in forehead,cheeks and PPR groups showed increased in forehead,cheeks,nose and chin by grey values compared to controls,and the cheeks,nose,chin with statistically significant differences between ETR and PPR.Plasma biomarkers IL-6, IL-1β, and TNF-α were significantly elevated in both ETR and PPR groups compared to controls. Conclusion: LSCI is a valuable, noninvasive tool for assessing blood flow dynamics in rosacea, providing a data foundation for clinical research. Different rosacea subtypes exhibit distinct lesion distribution and blood flow patterns, both ETR and PPR could affecting all facial areas,particularly the cheeks in ETR and the forehead, nose, chin in PPR.

    Keywords: Rosacea, Think View, LSCI, Facial Blood Perfusion, Dermatological Assessment, ETR, PPR, Multispectral Imaging Analyzer

    Received: 18 Apr 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Liao, Jiang, XIE, Lei, Luo, Lv, Liu, Liu, Song and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jin-Feng Liao, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Xue-Mei Jiang, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Hua Lei, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Juan Luo, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Gang Liu, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Wei Liu, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Si-Yuan Song, Baylor College of Medicine, Houston, 77030, Texas, United States
    Yi Wang, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China

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