AUTHOR=Liu Juan , Han Huafeng , Yang Binbin , Zhang Naifang , Li Jing , Chen Xicheng , Wu Jie , Zhao Yingying , Yang Yongsheng 

TITLE=Immunogenicity and protective efficacy of the HC009 mRNA vaccine against SARS-CoV-2

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1416375

DOI=10.3389/fimmu.2024.1416375

ISSN=1664-3224

ABSTRACT=<p>With the rapid global spread of COVID-19 and the continuous emergence of variants, there is an urgent need to develop safe and effective vaccines. Here, we developed a novel mRNA vaccine, HC009, based on new formulation by the QTsome delivery platform. Immunogenicity results showed that the prime-boost immunization strategy with HC009 was able to induce robust and durable humoral immunity, as well as Th1-biased cellular responses in rodents or non-human primates (NHPs). After further challenge with live SARS-CoV-2 virus, HC009 provided adequate protection against virus infection in hACE2 transgenic mice. Therefore, HC009 could provide significant immune protection against SARS-CoV-2.</p>