AUTHOR=Sun Zhe , Wei Ruoqu , Pan Chaolan , Ni Cheng , Zhang Xue , Guan Wenbin , Cheng Ruhong , Gu Yan , Yu Hong , He Kejun , Zhang Zhen , Yu Xia , Yao Zhirong 

TITLE=Successfully treated with siltuximab and prednisone in a 7-year-old girl with DOCK8-deficiency presenting as recurrent wart-like lesions: a case report

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1414573

DOI=10.3389/fimmu.2024.1414573

ISSN=1664-3224

ABSTRACT=<p>Dedicator of cytokinesis 8 (DOCK8) deficiency represents a primary immunodeficiency with a wide range of clinical symptoms, including recurrent infections, atopy, and increased malignancy risk. This study presents a case of a 6-year-old girl with <italic>DOCK8</italic> deficiency, characterized by severe, treatment-resistant herpetic infections who was successfully treated with siltuximab and glucocorticoids. The successful use of siltuximab in achieving remission highlights the pivotal role of interleukin-6 (IL-6) in <italic>DOCK8</italic> deficiency pathogenesis and suggests that IL-6 modulation can be critical in managing <italic>DOCK8</italic> deficiency-related viral infections, which may inform future therapeutic strategies for <italic>DOCK8</italic> deficiency and similar immunodeficiencies.</p>