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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Comparative Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1413849
This article is part of the Research Topic Thyroid eye diseases View all articles

The Phenotypic characteristics of Polymorphonuclear neutrophils and their correlation with B cell and CD4+T cell subsets in Thyroid-Associated Ophthalmopathy

Provisionally accepted
Ke Jin Ke Jin 1,2Qian Yao Qian Yao 3Bin Sun Bin Sun 1,2*
  • 1 The first clinical medical college, Shanxi Medical University, Taiyuan, Shanxi Province, China
  • 2 Department of Ophthalmology, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China
  • 3 Department of Ophthalmology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi Province, China

The final, formatted version of the article will be published soon.

    Introduction: Thyroid-associated ophthalmopathy (TAO) is considered to be an organ-specific autoimmune disease. Polymorphonuclear neutrophils (PMN) have been implicated in the pathogenesis of TAO. However, little is known about the role of PMN in development of TAO, much less the relationship between PMN with B cells and CD4+T cells in TAO. Objective: To investigate the phenotypic characteristics of PMN and the relationship between PMN with CD4+T cell and B cell subsets in the pathogenesis of TAO Methods: The blood routine information wa's collected from 135 TAO patients, 95 Grave's disease without TAO (GD) patients, and 116 normal controls (NC) while flow cytometry was used to assess the surface marker expression of PMN and the level of T cell and B cell subsets in peripheral blood from 40 TAO patients, 17 GD patients, and 45 NC.The level of PMN, CD62L+PMN, CD54+PMN, CD4+T cells and Th17 cells displayed increased in TAO patients than NC while Treg cells were lower in the TAO group compared to the NC. There was no statistical differences in Th1, B cells plasma cells among the groups.PMN were positively correlated with Th17 cells, but not the Th1, Treg and plasma cells.In the present study, we found the percentage of PMN and PMN subsets cells was significantly higher in TAO than in NC, and PMN were positively correlated with Th17 cells. It suggests that PMN may involve in the immunopathogenesis of TAO and modulate the response of Th17 cells.

    Keywords: Thyroid-associated ophthalmopathy, immunophenotype, polymorphonuclear neutrophils, B cell, CD4+T cell

    Received: 08 Apr 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Jin, Yao and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bin Sun, The first clinical medical college, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China

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