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REVIEW article
Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1410273
The Negative Effects of Extracellular Vesicles in the Immune System
Provisionally accepted- 1 Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
- 2 Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha, Anhui Province, China
Immunity is a critical self-defense mechanism of the human body, wherein immune cells and immune molecules play a crucial role. Extracellular vesicles (EVs), derived from immune cells or other cells, play a significant role in tumors, autoimmune diseases and other immune-related disorders by serving as carriers and facilitating intercellular communication through the transfer of cargoes. Numerous studies have revealed that EVs can exacerbate disease development by modulating immune responses. Therefore, this paper focuses on the effects of EVs on the number, activity and function of different types of immune cells and the release of immune molecules (such as cytokines, antigens, antibodies, etc) in various diseases, as well as the roles of EVs associated with different types of immune cells in various diseases. We aim to provide a comprehensive review of the negative effects that EVs play in the immune system to provide more ideas and strategies for the management of clinical immune diseases.
Keywords: extracellular vesicles, T cell, B cell, Neutrophil, monocyte, macrophage, immune
Received: 31 Mar 2024; Accepted: 03 Sep 2024.
Copyright: © 2024 Wang, Li, Wu, Mao, Zhu, Xie, Zhou, Wen and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chuan Wen, Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
Jidong Tian, Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha, Anhui Province, China
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