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REVIEW article

Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1410273

The Negative Effects of Extracellular Vesicles in the Immune System

Provisionally accepted
Yang Wang Yang Wang 1Cuifang Li Cuifang Li 1Feifeng Wu Feifeng Wu 1Jueyi Mao Jueyi Mao 1Junquan Zhu Junquan Zhu 1Haotian Xie Haotian Xie 1Xin Zhou Xin Zhou 1Chuan Wen Chuan Wen 1*Jidong Tian Jidong Tian 2*
  • 1 Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
  • 2 Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha, Anhui Province, China

The final, formatted version of the article will be published soon.

    Immunity is a critical self-defense mechanism of the human body, wherein immune cells and immune molecules play a crucial role. Extracellular vesicles (EVs), derived from immune cells or other cells, play a significant role in tumors, autoimmune diseases and other immune-related disorders by serving as carriers and facilitating intercellular communication through the transfer of cargoes. Numerous studies have revealed that EVs can exacerbate disease development by modulating immune responses. Therefore, this paper focuses on the effects of EVs on the number, activity and function of different types of immune cells and the release of immune molecules (such as cytokines, antigens, antibodies, etc) in various diseases, as well as the roles of EVs associated with different types of immune cells in various diseases. We aim to provide a comprehensive review of the negative effects that EVs play in the immune system to provide more ideas and strategies for the management of clinical immune diseases.

    Keywords: extracellular vesicles, T cell, B cell, Neutrophil, monocyte, macrophage, immune

    Received: 31 Mar 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 Wang, Li, Wu, Mao, Zhu, Xie, Zhou, Wen and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chuan Wen, Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
    Jidong Tian, Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha, Anhui Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.