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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1410018
This article is part of the Research Topic Cell Death in Cancer Immunology View all 13 articles

Ferroptosis: mechanism, Immunotherapy and role in ovarian cancer

Provisionally accepted
Guo K Guo K 1*Miao Lu Miao Lu 1Liancheng Zhu Liancheng Zhu 1*Tianyu Yao Tianyu Yao 1Jianlei Bi Jianlei Bi 2Jian Gao Jian Gao 1fang ren fang ren 1
  • 1 China Medical University, Shenyang, China
  • 2 Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Ovarian cancer is currently the second most common malignant tumor among gynecological cancers worldwide, primarily due to challenges in early diagnosis, high recurrence rates, and resistance to existing treatments. Current therapeutic options are inadequate for addressing the needs of ovarian cancer patients. Ferroptosis, a novel form of regulated cell death with demonstrated tumor-suppressive properties, has gained increasing attention in ovarian malignancy research. A growing body of evidence suggests that ferroptosis plays a significant role in the onset, progression, and incidence of ovarian cancer. Additionally, it has been found that immunotherapy, an emerging frontier in tumor treatment, synergizes with ferroptosis in the context of ovarian cancer. Consequently, ferroptosis is likely to become a critical target in the treatment of ovarian cancer.

    Keywords: ferroptosis, ovarian cancer, Xc system, MDSC, Immunotherapy

    Received: 31 Mar 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 K, Lu, Zhu, Yao, Bi, Gao and ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guo K, China Medical University, Shenyang, China
    Liancheng Zhu, China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.