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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1409149

Disulfidptosis classification of colorectal cancer reveals correlation with clinical prognosisand immune profile

Provisionally accepted
Ruanruan Yang Ruanruan Yang 1Chunxiao Lai Chunxiao Lai 1Luji Huang Luji Huang 2Feng Li Feng Li 3Weiqi Peng Weiqi Peng 1Meiyan Wu Meiyan Wu 1Jinge Xin Jinge Xin 1Yan Lu Yan Lu 2Manzhao Ouyang Manzhao Ouyang 2Yang Bai Yang Bai 1Shunhui He Shunhui He 2Yu Lin Yu Lin 1*
  • 1 Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
  • 2 Shunde Hospital, Southern Medical University, Foshan, Guangdong Province, China
  • 3 Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Colorectal cancer is one of the common malignant tumors worldwide, and early detection and diagnosis are crucial for improving the prognosis of patients with colorectal cancer. Recent research has found a new way of cell death: disulfidptosis.Under glucose starvation, abnormal accumulation of disulfide molecules such as Cystine in SLC7A11 overexpression cells induced disulfide stress to trigger cell death.The research on disulfidptosis is still in its early stages, and its role in disease progression is still unclear.In this study, we used a public database to detect the expression and mutations of disulfidptosis-related genes in COAD. We conducted clustering analysis based on disulfidptosis-related genes and analyzed differentially expressed disulfidptosis-related genes. A prognostic risk model was built using 7 disulfidptosis-related genes, and the reasons for prognostic differences were explored through immune infiltration analysis and drug sensitivity analysis. Finally, the expression of key genes were validated in clinical samples. Our research findings provide evidence for the role of disulfidptosis in COAD and offer new insights for personalized and precise treatment of COAD.

    Keywords: disulfidptosis, colorectal cancer, prognosis, drug sensitivity, Classification

    Received: 29 Mar 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Yang, Lai, Huang, Li, Peng, Wu, Xin, Lu, Ouyang, Bai, He and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yu Lin, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.