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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Systems Immunology
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1405020
This article is part of the Research Topic Decoding Immune-Vascular Dynamics for Lung Repair and Therapeutic Innovation View all articles
Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice
Provisionally accepted
Chenlin Wang
1*
Yanan Wu
1,2
Chao Liu
3
Yang Li
1*
Song Mi
1
Xiaofan Yang
1
Tong Liu
1
Yuanjing Tian
1*
YingYing Zhang
1*
Pingping Hu
1*
Lili Qiao
1*
Guodong Deng
1*
Ning Liang
1*
Jin-Yue Sun
3*
Yan Zhang
1*
Jiandong Zhang
1*- 1 Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
- 2 Department of Oncology, Shandong First Medical University, Jinan, China
- 3 Key Laboratory of Agro-Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences, Jinan, Shandong Province, China
Background: Patients receiving chest radiation therapy, or exposed to high radiation levels due to accidental nuclear leakage are at risk of radiation-induced lung injury (RILI). In innate immunity, macrophages not only exhibit certain radiation tolerance but also play an important regulatory role in the whole pathological process. Nervonic acid (NA), a long-chain unsaturated fatty acid found in nerve tissue, plays a pivotal role in maintaining normal tissue growth and repair. However, the influence of NA on RILI progression has yet to be examined. Aim: This study aimed to assess the role of macrophage subtypes in RILI and whether NA can alleviate RILI. Specifically, whether NA can alleviate RILI by targeting macrophages and reducing the levels of inflammatory mediators in mouse models was assessed. Methods: Mice RILI model was employed with 13 Gy whole thoracic radiation with or without administration of NA. Various assays were performed to evaluate lung tissue histological changes, cytokine expression, IκB-α expression and the number and proportion of macrophages. Results: The finding of this study revealed that rRadiation can lead to the release of inflammatory mediators, thereby exacerbatingwhich can worsen RILI. The specific radiation dose and duration of exposure can lead to different dynamic changes in the number of subpopulations of lung macrophages. NA can affect the changes of macrophages after irradiation and reduce inflammatory responses to alleviateimprove RILI. Conclusion: Macrophages play a significant role in the integrated pathological process of lung injury after irradiation which shows a dynamic change with different radiation doses and times. NA can protect lung tissues against the toxic effects of ionizing radiation and is a new potential functional component for targeting macrophages.interlobular septa, around bronchi, etc (6-8). They maintain homeostasis by engulfing inhaled particles and foreign pathogens, inducing the production of cytokines, and
Keywords: nuclear contamination, Radiation-induced lung injury, macrophage, nervonic acid, radiation therapy
Received: 22 Mar 2024; Accepted: 26 Nov 2024.
Copyright: © 2024 Wang, Wu, Liu, Li, Mi, Yang, Liu, Tian, Zhang, Hu, Qiao, Deng, Liang, Sun, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chenlin Wang, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Yang Li, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Yuanjing Tian, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
YingYing Zhang, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Pingping Hu, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Lili Qiao, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Guodong Deng, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Ning Liang, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Jin-Yue Sun, Key Laboratory of Agro-Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences, Jinan, Shandong Province, China
Yan Zhang, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
Jiandong Zhang, Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Province Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong Province, China
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