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REVIEW article

Front. Immunol.
Sec. Systems Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1403458

Exploring the Bone Marrow Micro environment in Thalassemia Patients: Potential Therapeutic Alternatives

Provisionally accepted
Zengzheng Li Zengzheng Li *Xiangmei Yao Xiangmei Yao jie zhang jie zhang jinghui yang jinghui yang junxue ni junxue ni Yajie Wang Yajie Wang *
  • The First People’s Hospital of Yunnan Province, Kunming, China

The final, formatted version of the article will be published soon.

    Genetic mutations in the β-globin gene lead to a decrease or removal of the β-globin chain, causing the build-up of unstable alpha-hemoglobin. This condition is referred to as beta-thalassemia (BT). The present treatment strategies primarily target the correction of defective erythropoiesis, with a particular emphasis on gene therapy and hematopoietic stem cell transplantation. However, the presence of inefficient erythropoiesis in BT bone marrow (BM) is likely to disturb the previously functioning BM microenvironment. This includes accumulation of various macromolecules, damage to hematopoietic function, destruction of bone cell production and damage to osteoblast(OBs), and so on. In addition, the changes of BT BM microenvironment may have a certain correlation with the occurrence of hematological malignancies. Correction of the microenvironment can be achieved through treatments such as iron chelation, antioxidants, hypoglycemia, and biologics. Hence, This review describes damage in the BT BM microenvironment and some potential remedies.

    Keywords: beta-Thalassemia, osteoblast, impaired hematopoiesis, Metabolic abnormalities, Ineffective erythropoiesis, Microenvironment correction

    Received: 19 Mar 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Li, Yao, zhang, yang, ni and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zengzheng Li, The First People’s Hospital of Yunnan Province, Kunming, China
    Yajie Wang, The First People’s Hospital of Yunnan Province, Kunming, China

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