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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Viral Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1403429

Primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome: A Mendelian randomization study

Provisionally accepted
Hao Wang Hao Wang 1Guanglei Chen Guanglei Chen 1Qian Gong Qian Gong 2Jing Wu Jing Wu 1Peng Chen Peng Chen 1*
  • 1 Guizhou University of Traditional Chinese Medicine, Guiyang, China
  • 2 Guangzhou University of Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Currently, evidence regarding the causal relationship between primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome is limited and inconsistent. Therefore, this study employs Mendelian randomization (MR) methodology to investigate the causal relationship between the two.Methods: This study selected 110 single-nucleotide polymorphisms (SNPs) of primary immunodeficiency-related genes as instrumental variables (IVs). Genetic associations of primary immunodeficiency-related genes were derived from recent genome-wide association studies (GWAS) data on human plasma protein levels and circulating immune cells. Data on genes associated with varicella-zoster virus reactivation syndrome were obtained from the GWAS Catalog and FINNGEN database, primarily analyzed using inverse variance weighting (IVW) and sensitivity analysis.Results: Through MR analysis, we identified 9 primary immunodeficiency-related genes causally associated with herpes zoster and its subsequent neuralgia; determined causal associations of 20 primary immunodeficiency-related genes with three vascular lesions (stroke, cerebral aneurysm, giant cell arteritis); revealed causal associations of 10 primary immunodeficiency-related genes with two ocular diseases (retinopathy, keratitis); additionally, three primary immunodeficiency-related genes each were associated with encephalitis, cranial nerve palsy, and gastrointestinal infections.This study discovers a certain association between primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome, yet further investigations are warranted to explore the specific mechanisms underlying these connections.

    Keywords: primary immunodeficiency-related genes, varicella-zoster virus reactivation syndrome, neurological complications, Mendelian randomization, two-sample study

    Received: 19 Mar 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Wang, Chen, Gong, Wu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Peng Chen, Guizhou University of Traditional Chinese Medicine, Guiyang, China

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