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MINI REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1401399

E-selectin in vascular pathophysiology

Provisionally accepted
Ju Liu Ju Liu 1,2*Jinjin Zhang Jinjin Zhang 1,2Shengshi Huang Shengshi Huang 3Zhiying Zhu Zhiying Zhu 1Alex Gatt Alex Gatt 4,5
  • 1 Shandong University, Jinan, China
  • 2 The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China
  • 3 Institute of Microvascular Medicine, The First Affiliated Hospital of Shandong First Medical University& Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China
  • 4 Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Tal-Qroqq, Malta
  • 5 Department of Pathology, Mater Dei Hospital, Tal-Qroqq, Malta

The final, formatted version of the article will be published soon.

    Selectins are a group of Ca 2+ -dependent, transmembrane type I glycoproteins which attract cell adhesion and migration. E-selectin is exclusively expressed in endothelial cells, and its expression is strongly enhanced upon activation by pro-inflammatory cytokines. The interaction of E-selectin with its ligands on circulating leukocytes captures and slows them down, further facilitating integrin activation, firm adhesion to endothelial cells and transmigration to tissues. Oxidative stress induces endothelial cell injury, leading to aberrant expression of E-selectin. In addition, the elevated level of E-selectin is positively related to high risk of inflammation. Dysregulation of E-selectin has been found in several pathological conditions including acute kidney injury (AKI), pulmonary diseases, hepatic pathology, Venous thromboembolism (VTE). Deletion of the E-selectin gene in mice somewhat ameliorates these complications.

    Keywords: E-Selectin, Inflammation, Oxidative Stress, Vascular Diseases, Therapeutic interventions

    Received: 15 Mar 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Liu, Zhang, Huang, Zhu and Gatt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ju Liu, Shandong University, Jinan, China

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