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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1400977
This article is part of the Research Topic Immunology at the feto-maternal interface View all 13 articles

The Role of Pyroptosis in the Occurrence and Development of Pregnancy Complications

Provisionally accepted
Jiahui Li Jiahui Li Min Wang Min Wang Haiyan Zhou Haiyan Zhou *Jin Zhong Jin Zhong *Haonan Yin Haonan Yin *Shu-Li Yang Shu-Li Yang *
  • Second Affiliated Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Pyroptosis is a form of programmed cell death that is crucial in the development of various diseases, including autoimmune diseases, atherosclerotic diseases, cancer, and pregnancy complications. In recent years, it has gained significant attention in national and international research due to its association with inflammatory immune overactivation and its involvement in pregnancy complications such as miscarriage and preeclampsia (PE). The mechanisms discussed include the canonical pyroptosis pathway of gasdermin activation and pore formation (caspase-1-dependent pyroptosis) and the non-canonical pyroptosis pathway (cysteoaspartic enzymes other than caspase-1). These pathways work on various cellular and factorial levels to influence normal pregnancy. This review aims to summarize and analyze the pyroptosis pathways associated with abnormal pregnancies and pregnancy complications. The objective is to enhance pregnancy outcomes by identifying various targets to prevent the onset of pyroptosis.

    Keywords: Cell Death, pyroptosis, Pregnancy Complications, Preeclampsia, GDM

    Received: 14 Mar 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Li, Wang, Zhou, Zhong, Yin and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haiyan Zhou, Second Affiliated Hospital of Jilin University, Changchun, China
    Jin Zhong, Second Affiliated Hospital of Jilin University, Changchun, China
    Haonan Yin, Second Affiliated Hospital of Jilin University, Changchun, China
    Shu-Li Yang, Second Affiliated Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.