AUTHOR=Chen Michael Y. , Zhang Felicia , Goedegebuure Simon Peter , Gillanders William E. 

TITLE=Dendritic cell subsets and implications for cancer immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1393451

DOI=10.3389/fimmu.2024.1393451

ISSN=1664-3224

ABSTRACT=<p>Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors, and inflammatory milieu all impact DCs with regard to promoting or inhibiting tumor immunity. The following review introduces important facets of DC function, and how subset and phenotype can affect the interplay of DCs with other factors in the tumor microenvironment. It will also discuss how current cancer treatment relies on DC function, and survey the myriad ways with which immune therapy can more directly harness DCs to enact antitumor cytotoxicity.</p>