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REVIEW article

Front. Immunol.
Sec. T Cell Biology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1393418
This article is part of the Research Topic Regulatory T cells in Immune-mediated diseases View all 13 articles

The role of Th/Treg immune cells in osteoarthritis

Provisionally accepted
Zhi Wen Zhi Wen 1,2Liguo Qiu Liguo Qiu 2Zifeng Ye Zifeng Ye 2Xuyi Tan Xuyi Tan 3XU Xiaotong XU Xiaotong 4Min Lu Min Lu 1*Gaoyan Kuang Gaoyan Kuang 1*
  • 1 The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
  • 2 Hunan University of Chinese Medicine, Changsha, China
  • 3 Department of Joint orthopedics, The Affiliated Hospital, Hunan Academy of Traditional Chinese Medicine, Changsha, Anhui Province, China
  • 4 Department of Joint orthopedics, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China

The final, formatted version of the article will be published soon.

    Osteoarthritis (OA) is a prevalent clinical condition affecting the entire joint, characterized by its multifactorial etiology and complex pathophysiology. The onset of OA is linked to inflammatory mediators produced by the synovium, cartilage, and subchondral bone, all of which are closely tied to cartilage degradation.Consequently, OA may also be viewed as a systemic inflammatory disorder. Emerging studies have underscored the significance of T cells in the development of OA. Notably, imbalances in Th1/Th2 and Th17/Treg immune cells may play a crucial role in the pathogenesis of OA. This review aims to compile recent advancements in understanding the role of T cells and their Th/Treg subsets in OA, examines the immune alterations and contributions of Th/Treg cells to OA progression, and proposes novel directions for future research, including potential therapeutic strategies for OA.

    Keywords: OA, T cells, Th1/Th2, Th17/Treg, immune cells, Inflammation

    Received: 29 Feb 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Wen, Qiu, Ye, Tan, Xiaotong, Lu and Kuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Min Lu, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
    Gaoyan Kuang, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.