AUTHOR=Chen Zhiyi , Xu Qianchun , Shou Zhangfei 

TITLE=Application of CD38 monoclonal antibody in kidney disease

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1382977

DOI=10.3389/fimmu.2024.1382977

ISSN=1664-3224

ABSTRACT=<p>CD38 antigen is a glycoprotein that found on the surface of several immune cells, and this property makes its monoclonal antibodies have the effect of targeted elimination of immune cells. Therefore, the CD38 monoclonal antibody (such as daratumumab, Isatuximab) becomes a new treatment option for membranous nephropathy, lupus nephritis, renal transplantation, and other refractory kidney diseases. This review summarizes the application of CD38 monoclonal antibodies in different kidney diseases and highlights future prospects.</p>