AUTHOR=Li Hong-yang , Liu Tie-mei 

TITLE=Platelet indices and inflammatory bowel disease: a Mendelian randomization study

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1377915

DOI=10.3389/fimmu.2024.1377915

ISSN=1664-3224

ABSTRACT=Background: Platelets play a significant role in the innate and adaptive processes of immunity and inflammation. Inflammatory bowel disease (IBD) is an autoimmune disease that is widely understood to be caused by a combination of genetic predisposition, aberrant immune responses, etc. Methods: To examine the relationships between genetically determined platelet indices and IBD, we conducted a Mendelian randomization (MR) study. Data associated with platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) were used from the UK Biobank. The outcome data, including IBD, Crohn's disease (CD), ulcerative colitis (UC), were from the FinnGen database. The inverse variance-weighted (IVW), MR-Egger, weighted median methods were used for MR analyses. Results: The MR estimations from the IVW approach show a significant connection between PLT and IBD. Similarly, PCT and IBD have a positive causal relationship following the IVW and MR-Egger approaches. While PLT and PCT increased the risk of CD, PDW increased the likelihood of UC. PLT and PCT to CD have strong causal relationships with CD, according to the findings of all three approaches respectively. Nevertheless, PDW was the only relevant indicator of UC. UC risk that was enhanced. The only significant result was IVW's. Conclusions: Our findings suggest that the fluctuation of platelet indicators is of great significance in the development of IBD. platelet indices may affect IBD. PLT and PCT have a close association with an impact on IBD and CD, respectively; PDW only has a connection with affects UC. Platelets play an important role in the progression development of IBD (UC, CD).