Skip to main content

REVIEW article

Front. Immunol.
Sec. B Cell Biology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1376723
This article is part of the Research Topic IgG4 Autoantibodies in the Context of IgG4 Autoimmunity View all 17 articles

Immunoglobulin G4 in primary Sjögren's syndrome and IgG4-related diseaseconnections and dissimilarities

Provisionally accepted
Maria Maslinska Maria Maslinska *Kinga Kostyra-Grabczak Kinga Kostyra-Grabczak
  • National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland

The final, formatted version of the article will be published soon.

    Primary Sjogren's syndrome (pSS) is an autoimmune disease, with B cell hyperactivation and the autoantibodies production as its immunological hallmarks. Although the distinction between the immunoglobulin G4-related disease (IgG4-RD) and pSS, based on the presence or absence of certain autoantibodies, seems easy to make, the serum IgG4 concentration and often similar organ involvement may lead to a misdiagnosis. The increased serum concentration of IgG4 in IgG4-RD is not clearly linked to the pathogenesis of IgG-RD and it's been suggested that it may constitute just an epiphenomenon. The aim of this article is to discuss the presence of IgG4 in pSS and IgG4-RD and its potential significance for these two diseases.

    Keywords: Immunoglobulin G4, Sjogren's Syndrome, IgG4-related disease, Autoimmunity, lymphomas

    Received: 26 Jan 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Maslinska and Kostyra-Grabczak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Maria Maslinska, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.