Skip to main content

REVIEW article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1373769
This article is part of the Research Topic Vascular Injury in Systemic Diseases: Current Concepts and Future Perspectives View all 4 articles

Case report: granulomatosis with polyangiitis patient presented with a mass in aortic root

Provisionally accepted
Yinyan Teng Yinyan Teng 1Mei Chen Mei Chen 2Zhongwei Chen Zhongwei Chen 1Xiaowei Zhang Xiaowei Zhang 1Zhongyun Li Zhongyun Li 1Shusheng Liao Shusheng Liao 1*
  • 1 First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
  • 2 Department of Ultrasonography, Ningbo First Hospital, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Granulomatosis with polyangiitis (GPA) is an autoimmune inflammatory disease that affects small-and medium-sized blood vessels in the body, representing a rare entity.Cardiac involvement was identified as an independent risk factor for death in GPA patients, yet it has not been systematically elucidated in previous literature. Cardiac lesions in patients with GPA can manifest in various ways, such as pericarditis, myocarditis, coronary vasculitis, valvular abnormalities, conduction system abnormalities and heart failure. Herein, we report a 55-year-old woman with GPA, she had 2 years history of recurrent episodes of headache, accompanying sick and fatigue, and aggravated for the past half-month. The main manifestation is presenting as a mass in the aortic root, which was successfully diagnosed by multimodality imaging (including two-dimensional echocardiography, contrast-enhanced ultrasound and CT). After medicine treatment with methylprednisolone and cyclophosphamide, the patient's symptoms significantly improved and remained asymptomatic over 6 months of follow-up. This article will enrich our knowledge about cardiac involvement in GPA patients and highlights the value of imaging, especially ultrasound, in the diagnosis and post-treatment follow-up of this condition.

    Keywords: Granulomatosis with polyangiitis, diagnosis, Heart, Echocardiography, therapy

    Received: 20 Jan 2024; Accepted: 22 Oct 2024.

    Copyright: © 2024 Teng, Chen, Chen, Zhang, Li and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shusheng Liao, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.