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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Mucosal Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1373766
This article is part of the Research Topic Immunological Consequences of Antigen Sampling at Mucosal Surfaces - Volume II View all 6 articles

Food antigens suppress small intestinal tumorigenesis

Provisionally accepted
Takaharu Sasaki Takaharu Sasaki 1Yuna Ota Yuna Ota 1Yui Takikawa Yui Takikawa 1Tommy Terrooatea Tommy Terrooatea 1Takashi Kanaya Takashi Kanaya 1Masumi Takahashi Masumi Takahashi 1Naoko Taguchi-Atarashi Naoko Taguchi-Atarashi 1Naoko Tachibana Naoko Tachibana 1Haruka Yabukami Haruka Yabukami 1Charles D. Surh Charles D. Surh 2Aki Minoda Aki Minoda 1Kwang Soon Kim Kwang Soon Kim 2Hiroshi Ohno Hiroshi Ohno 1*
  • 1 RIKEN Yokohama, Yokohama, Japan
  • 2 Pohang University of Science and Technology, Pohang, North Gyeongsang, Republic of Korea

The final, formatted version of the article will be published soon.

    Food components suppressing small intestinal tumorigenesis are not well-defined partly because of the rarity of this tumor type compared to colorectal tumors (1). Using Apc min/+ mice, a mouse model for intestinal tumorigenesis, and antigen-free diet, we report here that food antigens serve this function in the small intestine. By depleting Peyer's patches (PPs), immune inductive sites in the small intestine, we found that PPs have a role in the suppression of small intestinal tumors and are important for the induction of small intestinal T cells by food antigens. On the follicle-associated epithelium (FAE) of PPs, microfold (M) cells pass food antigens from lumen to the dendritic cells to induce T cells. Single cell RNA-seq (scRNA-seq) analysis of immune cells in PPs revealed a significant impact of food antigens on the induction of the PP T cells and the antigen presentation capacity of dendritic cells. These data demonstrate the role of food antigens in the suppression of small intestinal tumorigenesis by PP-mediated immune cell induction.

    Keywords: Food antigens, Intestinal tumor, Peyer´s patches, M cells, microfold cells, ScRNA-seq analysis, T cells, dendritic cell (DC)

    Received: 20 Jan 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Sasaki, Ota, Takikawa, Terrooatea, Kanaya, Takahashi, Taguchi-Atarashi, Tachibana, Yabukami, D. Surh, Minoda, Kim and Ohno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hiroshi Ohno, RIKEN Yokohama, Yokohama, Japan

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