AUTHOR=Niu Huifang , Zhou Minfeng , Zogona Daniel , Xing Zheng , Wu Ting , Chen Rui , Cui Dandan , Liang Fengxia , Xu Xiaoyun 

TITLE=Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1370658

DOI=10.3389/fimmu.2024.1370658

ISSN=1664-3224

ABSTRACT=<p>Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of <italic>Akkermansia muciniphila</italic> and the occurrence of metabolic diseases. <italic>A. muciniphila</italic>, a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivatives have various physiological functions, including treating metabolic disorders and maintaining human health. This review systematically explicates the abundance change rules of <italic>A. muciniphila</italic> in metabolic diseases. It also details the high efficacy and specific molecules mechanism of <italic>A. muciniphila</italic> and its derivatives in treating obesity, type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease.</p>