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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1361657

Scinderin is a potential prognostic biomarker and correlated with immunological regulation: from pan-cancer analysis to liver hepatocellular carcinoma

Provisionally accepted
Shengyong Zhai Shengyong Zhai 1Yuhua Li Yuhua Li 1Yuanyuan Yang Yuanyuan Yang 2Wei Lang Wei Lang 1Xiaoxia Liu Xiaoxia Liu 3Kai Liu Kai Liu 1Jianjun Qu Jianjun Qu 1Lingyu Zhu Lingyu Zhu 4*
  • 1 Department of Gastrointestinal Surgery, Affiliated Hospital of Weifang Medical University, Weifang, China
  • 2 Department of Nuclear Medicine, Weifang People's Hospital, Weifang, China
  • 3 Department of Anaesthesiology, Weifang People's Hospital, Weifang, China
  • 4 Affiliated Hospital of Weifang Medical University, Weifang, China

The final, formatted version of the article will be published soon.

    Aim: This study aimed to systematically dissect the role of Scinderin (SCIN) in tumorigenesis.Methods: bioinformatics Bioinformatics techniques were employed based on cancer data from TCGA, ENCORI, HPA, GEPIA2, UALCAN, Kaplan-Meier plotter, TIMER, TISIDB, cBioPortal, HCCDB, GeneMANIA and LinkedOmics data-base.Experiments in vitro and in vivo were conducted to dissect the role of SCIN in liver hepatocellular carcinoma (LIHC).Results: Significantly differential expression of SCIN was found in nine types of cancers, including LIHC. Through pan-cancer analysis, the correlations between SCIN expression with prognosis and immune cell infiltration were proven, especially in LIHC, ovarian serous cystadenocarcinoma and lung adenocarcinoma. The highest frequency of alteration in SCIN (6.81%) was seen in patients with uterine corpus endometrial carcinoma, in which "mutation" was the predominant type, with a frequency of about 5.29%; meanwhile, S673F and S381Y were the two most frequent mutation sites. Furthermore, the abnormal expression of SCIN exhibited a strong relationship with immune cell subtypes, immune checkpoint genes, tumour mutation burden, microsatellite instability, neoantigens, molecular subtypes, mismatch repair signatures and DNA methyl-transferase in different cancer types. Through comparative analysis, we discovered that SCIN was dramatically up-regulated in LIHC, and associated with poor survival. Experiments in vitro and in vivo suggested the knock-down of SCIN could suppress tumor cell proliferation and improve the

    Keywords: Scinderin (SCIN), bioinformatics, Pan-cancer analysis, prognosis, liver hepatocellular carcinoma

    Received: 26 Dec 2023; Accepted: 05 Jul 2024.

    Copyright: © 2024 Zhai, Li, Yang, Lang, Liu, Liu, Qu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lingyu Zhu, Affiliated Hospital of Weifang Medical University, Weifang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.