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BRIEF RESEARCH REPORT article

Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1356004

Mouse monocytes express CD127 by immune cells, not LPS

Provisionally accepted
Reza Yazdani Reza Yazdani Mozhde Askari Mozhde Askari Amir M. Ahmadi Amir M. Ahmadi Gholamreza Azizi Gholamreza Azizi Bogoljub Ciric Bogoljub Ciric Alexandra Boehm Alexandra Boehm Guang-Xian Zhang Guang-Xian Zhang Abdolmahamad Rostami Abdolmahamad Rostami *
  • Department of Neurology,Thomas Jefferson University, Philadelphia, Pennsylvania, United States

The final, formatted version of the article will be published soon.

    The essential role of interleukin 7 (IL-7) signaling via its receptor (IL-7R; CD127) in T cell development and function has been well documented. However, CD127 expression and function in myeloid cells, including monocytes, are less clear, especially in mice. In the present study we report an inducible CD127 expression in mouse monocytes/macrophages. This induction is dependent on the presence of other immune cells, highlighting that regulation of CD127 expression on monocytes differs in mice and humans. We demonstrate that CD127 is functional, as IL-7 downregulated its expression. We also saw decreased CD127 expression during inflammation in vivo.Overall, upregulation of CD127 expression in vitro and its downregulation in vivo confirm that CD127 is an inducible marker on mouse monocyte/macrophage cells, in contrast to findings recently published by others. Characterizing the role of CD127 signaling in myeloid cells in inflammatory disorders would be worthwhile in future study.

    Keywords: IL-7 receptor, CD127, monocyte, macrophage, IL-7, Inflammation

    Received: 14 Dec 2023; Accepted: 26 Aug 2024.

    Copyright: © 2024 Yazdani, Askari, Ahmadi, Azizi, Ciric, Boehm, Zhang and Rostami. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Abdolmahamad Rostami, Department of Neurology,Thomas Jefferson University, Philadelphia, 19107, Pennsylvania, United States

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