AUTHOR=Wu Shuang , Tan Yicheng , Li Fanfan , Han Yixiang , Zhang Shenghui , Lin Xiaofei 

TITLE=CD44: a cancer stem cell marker and therapeutic target in leukemia treatment

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1354992

DOI=10.3389/fimmu.2024.1354992

ISSN=1664-3224

ABSTRACT=<p>CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.</p>