AUTHOR=Beilinson Helen A. , Erickson Steven A. , Golovkina Tatyana 

TITLE=The endogenous Mtv8 locus and the immunoglobulin repertoire

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1345467

DOI=10.3389/fimmu.2024.1345467

ISSN=1664-3224

ABSTRACT=<p>The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient immune responses against a wide number of pathogens. The antigen receptor repertoire is built during the recombination of B and T cell receptor (BCR, TCR) loci and hypermutation of BCR loci. V(D)J recombination rearranges these antigen receptor loci, which are organized as an array of separate V, (D), and J gene segments. Transcription activation at the recombining locus leads to changes in the local three-dimensional architecture, which subsequently contributes to which gene segments are utilized for recombination. The endogenous retrovirus (ERV) mouse mammary tumor provirus 8 (<italic>Mtv8</italic>) resides on mouse chromosome 6 interposed within the large array of light chain kappa V gene segments. As ERVs contribute to changes in genomic architecture by driving high levels of transcription of neighboring genes, it was suggested that <italic>Mtv8</italic> could influence the BCR repertoire. We generated <italic>Mtv8</italic>-deficient mice to determine if the ERV influences V(D)J recombination to test this possibility. We find that <italic>Mtv8</italic> does not influence the BCR repertoire.</p>